Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168) (HB004025)

Name: Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168)
Brand: abinScience
SKU: HB004025
Price: 194 USD
Availability: InStock

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개요

카탈로그 번호	HB004025
설명	Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168) [1A168] (HB004025) is a mouse monoclonal antibody detecting PECAM1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
종 반응성	Human
응용 분야	ELISA, IHC, WB
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG1
클론 ID	1A168
면역원	Mammalian cells - derived recombinant Human CD31 / PECAM1 (Met1-Lys601).
타겟	PECAM-1, Platelet endothelial cell adhesion molecule, GPIIA', PECAM1, PECA1, EndoCAM, CD31,
정제	Protein A/G purified from cell culture supernatant.
등록번호	P16284
형태	Liquid
저장 완충액	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium azide. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Platelet endothelial cell adhesion molecule (CD31/PECAM1) is a ~82 kDa protein. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. 1. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308 2. Dasgupta, B. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 5041-51. PMID: 19342684 3. Hu, M. et al. (2016) Scientific reports 6, 38655. PMID: 27958302 4. Brown, S. et al. (2002) Nature 418, 200-3. PMID: 12110892 5. Yeh, JC. et al. (2008) Biochemistry 47, 9029-39. PMID: 18672896
참고사항	For research use only.