

| 카탈로그 번호 | HV211021 |
|---|---|
| 설명 |
Recombinant Human CD300LF Protein, C-Fc (HV211021) expressed in Mammalian Cells, spanning Thr20-Leu155. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | Mammalian cells |
| 등록번호 | Q8TDQ1 |
| 단백질 길이 | Thr20-Leu155 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 43.74 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CD300 antigen-like family member F, CD300F, CD300LF, CD300f, CLM-1, CLM1, CMRF35-like molecule 1, IGSF13, IREM-1, IREM1, IgSF13, Immune receptor expressed on myeloid cells 1, Immunoglobulin superfamily member 13, NK inhibitory receptor, NKIR |
| 배경 | CMRF35-like molecule 1 is a ~32 kDa protein. Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). 1. Alvarez-Errico, D. et al. (2004) European journal of immunology 34, 3690-701. PMID: 15549731 2. Izawa, K. et al. (2014) The Journal of allergy and clinical immunology 133, 270-3.e1-7. PMID: 24035150 3. Kim, EJ. et al. (2012) Immunology 135, 226-35. PMID: 22043923 |
| 참고사항 | For research use only |
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