Anti-Human IL-17RA/IL-17R Reference Antibody (Brodalumab, RUO) (HV263016)

Name: Anti-Human IL-17RA/IL-17R Reference Antibody (Brodalumab, RUO)
Brand: abinScience
SKU: HV263016
Price: 176 USD
Availability: InStock

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100ug
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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HV263016
설명	Brodalumab (HV263016) is a research-grade recombinant antibody targeting CD217. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG2-kappa
발현 시스템	Mammalian cells
테스트된 응용 분야	FCM
타겟	IL17R, CDw217, IL-17RA, Interleukin-17 receptor A, IL-17 receptor A, IL17RA, CD217
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q96F46
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	AMG827, KHK4827, 1174395-19-7
배경	Interleukin-17 receptor A (CD217/IL17RA) is a ~96 kDa protein. Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A. Receptor for IL17F. Binds to IL17A with higher affinity than to IL17F. Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. 1. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633 2. Yao, Z. et al. (1997) Cytokine 9, 794-800. PMID: 9367539 3. Ely, LK. et al. (2009) Nature immunology 10, 1245-51. PMID: 19838198 4. Toy, D. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 177, 36-9. PMID: 16785495 5. Wright, JF. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 2799-805. PMID: 18684971 6. Puel, A. et al. (2011) Science (New York, N.Y.) 332, 65-8. PMID: 21350122 7. Boisson, B. et al. (2013) Immunity 39, 676-86. PMID: 24120361
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107)

이미지

Bioactivity

SEC-HPLC detection for Research Grade Brodalumab.
SDS-PAGE

SDS-PAGE for Research Grade Brodalumab.
Flow cytometry

Flow-cytometry using anti-human CD217 antibody. THP-1 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD217 monoclonal antibody (Catalog HV263016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.