| Catalog No. | HB185016 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Humanized |
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| Isotype | IgG4-kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, CD33, gp67, SIGLEC3 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
P20138 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | CDP-771, CMA-676(ADC), WAY-CMA-676, gemtuzumabozogamicin, 220578-59-6 |
|---|
| Background | Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen, which present on leukemic myeloblasts of acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin . Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia.
• Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation., PMID:32803224
• Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis., PMID:34530055
• Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia., PMID:34188106
• CD33 isoforms in microglia and Alzheimer's disease: Friend and foe., PMID:35940942
• Siglecs in Brain Function and Neurological Disorders., PMID:31546700
• SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection., PMID:34060491
• Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab-Auristatin Conjugate with a Wide Therapeutic Window., PMID:38561023
• CD33 as a leukocyte-associated marker expressed on human spermatozoa., PMID:37081561
• Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease., PMID:35452678
• Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype., PMID:33539598
|
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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