| Catalog No. | HY110026 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Chimeric |
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| Isotype | IgG1-kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
SAA, Serum amyloid A-1 protein, SAA1, Amyloid fibril protein AA |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
P0DJI8 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | 11-1F4, CAEL101, CAEL-101, NSC-711516, 2414866-63-8 |
|---|
| Background | Anselamimab (CAEL-101) a humanized IgG1-κ anti-Amyloid fibrils antibody targeting to serum amyloid A1 (SAA1).
• Overexpression of serum amyloid a 1 induces depressive-like behavior in mice., PMID:27608955
• Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2., PMID:23223242
• Serum amyloid A levels are associated with polymorphic variants in the serum amyloid A 1 and 2 genes., PMID:30852808
• Large-scale isotype-specific quantification of Serum amyloid A 1/2 by multiple reaction monitoring in crude sera., PMID:22300576
• Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis., PMID:18815155
• Diversity and complexity of the mouse Saa1 and Saa2 genes., PMID:24521869
• The role of PPAR activation during the systemic response to brain injury., PMID:25994490
• Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A., PMID:20890286
• Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice., PMID:21996012
• Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7., PMID:7698755
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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