| Catalog No. | HB949026 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | Fusion-[human activin receptor type 2-A (activin receptor type IIA, ACTR-IIA) extracellular domain (ECD) fragment (1-109) engineered varian]2-IgG1-Fc (Fragment constant) |
|---|
| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
ACVR2, ACTRIIA, ACTR-IIA, Activin receptor type IIA, ACVR2A, Activin receptor type-2A |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Purified by Nickel column. |
| Accession |
P27037 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | 2727114-26-1 |
|---|
| Background | Elritercept (KER-050) is a recombinant fusion protein comprising a modified activin receptor type IIA extracellular domain fused to a human IgG1 Fc. Elritercept inhibits activin A and other select TGF-β superfamily ligands.
• Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass., PMID:28659341
• Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer., PMID:33420656
• Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis., PMID:34099644
• Gene expression and silencing of activin receptor type 2A (ACVR2A) in myoblast cells of chicken., PMID:27635666
• Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition., PMID:35643319
• Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B., PMID:32270195
• The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice., PMID:35013323
• Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2., PMID:37378449
• Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells., PMID:29620144
• A molecular study of synovial chondromatosis., PMID:31589790
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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