| Catalog No. | HB112016 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Human |
|---|
| Isotype | IgG4-lambda2 |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
CD116, CSF2R, GMR-alpha, CSF2RA, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, CSF2RY, GMCSFR-alpha, GM-CSF-R-alpha, CDw116 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
P15509 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | CAM-3001, 1085337-57-0 |
|---|
| Background | Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophage colony stimulating factor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death.
• A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption., PMID:35043685
• miR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable Atherosclerotic Plaque Formation., PMID:32473103
• Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain., PMID:32365364
• Modeling pulmonary alveolar proteinosis with induced pluripotent stem cells., PMID:24428646
• GM-CSF as a therapeutic target in inflammatory diseases., PMID:23933508
• The Relationship Between Cytokine Production, CSF2RA, and IL1R2 Expression in Mammary Adenocarcinoma, Tumor Histopathological Parameters, and Lymph Node Metastasis., PMID:31635541
• Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease., PMID:30124884
• Quantitative Lipidomics in Pulmonary Alveolar Proteinosis., PMID:31002528
• STAT3-activated GM-CSFRα translocates to the nucleus and protects CLL cells from apoptosis., PMID:24836891
• Toll-like receptor-mediated eosinophil-basophil differentiation: autocrine signalling by granulocyte-macrophage colony-stimulating factor in cord blood haematopoietic progenitors., PMID:23347362
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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