| Catalog No. | HV303016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-lambda |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | RGM domain family member A, RGMA, RGM, Repulsive guidance molecule A |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q96B86 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | ABT-555, AE12-1Y-QL(derivedfromparentalmAbAE12-1andAE12-1Y), 1791416-49-3 |
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| Background | Elezanumab is a fully humanized monoclonal antibody directed against repulsive guidance molecule A (RGMa). Studies in patients with multiple sclerosis (MS) demonstrate RGMa upregulation, which inhibits axonal growth and myelination, oligodendroglial regeneration and functional recovery after trauma or inflammation. Elezanumab treatment promoted axon regeneration, neuroprotection, remyelination, and immune modulation in several MS-relevant preclinical models. Elezanumab was previously well-tolerated as a single dose to healthy volunteers.
• Molecular biology, genetics and biochemistry of the repulsive guidance molecule family., PMID:19698085
• Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development., PMID:15053976
• DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties., PMID:14985445
• TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule., PMID:21645559
• Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex., PMID:32576689
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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