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Research Grade Anti-RGMA/RGM Antibody (H116A3) (HV303026)

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Research Grade Anti-RGMA/RGM Antibody (H116A3)

Research Grade Anti-RGMA/RGM Antibody (H116A3)

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Spec:

100ug
1mg

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Overview
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Datasheet

Overview

Catalog No.	HV303026
Description	Anti-RGMA/RGM Antibody (H116A3) (HV303026) is a research-grade recombinant antibody targeting RGM domain family member A. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG1-Kappa
Clone ID	H116A3
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	RGM domain family member A, RGMA, RGM, Repulsive guidance molecule A
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q96B86
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Background	Repulsive guidance molecule A (RGMA) is a ~49 kDa protein. Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Anti-RGMA/RGM Antibody (H116A3)

References

Datasheet

Research Grade Anti-RGMA/RGM Antibody (H116A3).pdf

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Research Grade Anti-RGMA/RGM Antibody (H116A3)