Anti-Human RGM-A Reference Antibody (Elezanumab, RUO) (HV303016)

Name: Anti-Human RGM-A Reference Antibody (Elezanumab, RUO)
Brand: abinScience
SKU: HV303016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HV303016
Description	Elezanumab (HV303016) is a research-grade recombinant antibody targeting RGM domain family member A. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-lambda
Expression system	Mammalian cells
Clonality	Monoclonal
Target	RGM domain family member A, RGMA, RGM, Repulsive guidance molecule A
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q96B86
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ABT-555, AE12-1Y-QL(derivedfromparentalmAbAE12-1andAE12-1Y), 1791416-49-3
Background	Repulsive guidance molecule A (RGMA) is a ~49 kDa protein. Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SEC-HPLC

SEC-HPLC detection for Research Grade Elezanumab.
Bioactivity

Detects RGMA in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Elezanumab

References

Datasheet

Anti-Human RGM-A Reference Antibody (Elezanumab, RUO).pdf

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Recombinant Proteins

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Anti-Human RGM-A Reference Antibody (Elezanumab, RUO) (HV303016)

Overview

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References

Datasheet

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