| Catalog No. | HF869016 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Isotype | Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant) |
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| Expression system | Mammalian Cells |
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| Target | GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | O95390 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | ACE-536, luspatercept–aamt, 1373715-00-4 |
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| Background | Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.
• GDF11: An emerging therapeutic target for liver diseases and fibrosis., PMID:38494851
• Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth., PMID:29503194
• GDF11/BMP11 activates both smad1/5/8 and smad2/3 signals but shows no significant effect on proliferation and migration of human umbilical vein endothelial cells., PMID:26919250
• GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling., PMID:33684566
• Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11., PMID:10391213
• Induction of reparative dentin formation by ultrasound-mediated gene delivery of growth/differentiation factor 11., PMID:12718768
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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