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Anti-Human GDF11/BMP11 Antibody (SAA0431) (HF869207)

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Anti-Human GDF11/BMP11 Antibody (SAA0431)

Anti-Human GDF11/BMP11 Antibody (SAA0431)

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Overview

Catalog No.	HF869207
Description	Anti-Human GDF11/BMP11 Antibody (SAA0431) [SAA0431] (HF869207) is a mouse monoclonal antibody detecting GDF11 in ELISA, FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0431
Clonality	Monoclonal
Target	GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O95390
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Growth/differentiation factor 11 (GDF11/BMP11) is a ~45 kDa protein. Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. 1. Cox, TC. et al. (2019) Human mutation 40, 1813-1825. PMID: 31215115 2. Walker, RG. et al. (2017) BMC biology 15, 19. PMID: 28257634
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Anti-Human GDF11/BMP11 Antibody (SAA0431)

References

Datasheet

Anti-Human GDF11/BMP11 Antibody (SAA0431).pdf

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Anti-Human GDF11/BMP11 Antibody (SAA0431)