| Catalog No. | HT343066 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Isotype | Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant) |
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| Expression system | Mammalian Cells |
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| Target | GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | O14793 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | ACE-031, ActRIIB-IgG1, ActRIIb:FcFusionProtein, HGT-4510, RAP-031, 1169766-01-1 |
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| Background | Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.
• Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454
• Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826
• GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905
• Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196
• Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042
• Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097
• Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925
• Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254
• Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022
• Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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