| Catalog No. | HF943036 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | Fusion - [IL1RAP (interleukin-1 receptor accessory protein) - IL1R1 (type 1 interleukin-1 receptor, interleukin 1 receptor, type I)]2 - IGHG1 Fc (Fragment constant) |
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| Expression system | Mammalian Cells |
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| Target | Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P01584 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 501081-76-1 |
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| Background | Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes.
• Understanding the mechanism of IL-1β secretion., PMID:22019906
• NLRP3 inflammasome mediates M1 macrophage polarization and IL-1β production in inflammatory root resorption., PMID:31976565
• The role of IL-1β and TNF-α in intervertebral disc degeneration., PMID:32853910
• Human Monocytes Engage an Alternative Inflammasome Pathway., PMID:27037191
• D-mannose suppresses macrophage IL-1β production., PMID:33311467
• BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity., PMID:29324233
• Association of interleukin-6 and interleukin-1-β levels in patients with toxoplasmosis., PMID:35782407
• Interleukin-1 beta is significantly upregulated in the decidua of spontaneous and recurrent miscarriage placentas., PMID:33545613
• The effect of interleukin 1 beta blockade on the tumor microenvironment., PMID:33493144
• Single-cell profiling identifies IL1Bhi macrophages associated with inflammation in PD-1 inhibitor-induced inflammatory arthritis., PMID:38453911
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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