Gevokizumab ELISA Kit (DF943028)

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Overview

Catalog No.	DF943028
Sample type	Plasma, Serum
Sensitivity	0.156 μg/ml
Range	0.31-5 μg/mL
Accession	P01584
Applications	ELISA
Detection method	Colorimetric
Assay type	Quantitative
Recovery	80-120%
Shipping	2-8 ℃
Stability and Storage	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
Specifications	Gevokizumab
Alternate Names	XOMA 052, 1129435-60-4
Background	Interleukin-1 beta (Gevokizumab) is a ~30 kDa protein. Potent pro-inflammatory cytokine (1,2,3,4). Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (4). Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (1). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (2). References: 1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 2. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819 3. LaRock, CN. et al. (2016) Science immunology 1. PMID: 28331908 4. Van Damme, J. et al. (1985) Nature 314, 266-8. PMID: 3920526 5. Tian, XX. et al. (2021) International endodontic journal 54, 916-925. PMID: 33377178 6. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744
Note	For Research Use Only.