What is PEG?

PEG (polyethylene glycol, or poly[ethylene glycol]) is a synthetic polymer composed of repeating ethylene glycol units with the structure (O-CH₂-CH₂)n. It is highly water-soluble, non-toxic, non-antigenic, and biocompatible, making it ideal for pharmaceutical and biomedical applications. PEGs are classified by molecular weight (MW), ranging from low-MW oligomers to high-MW polymers.

Why use an anti-PEG antibody?

Anti-PEG antibodies are essential tools for studying the pharmacokinetics (PK) and immunogenicity of PEGylated therapeutics. They enable precise detection and quantification of PEG in biological samples, supporting:

• Distribution and clearance profiling
• Metabolism and excretion studies
• Anti-drug antibody (ADA) assays for PEGylated biologics
• Quality control in bioconjugation processes

What PEG-related products are available?

We offer a comprehensive suite of high-affinity anti-PEG reagents for research and assay development:

• Rabbit monoclonal anti-PEG antibodies (clone-specific, high sensitivity)
• PEG detection ELISA kits (quantitative, validated)
• Biotinylated and HRP-conjugated anti-PEG for IHC/WB
• Custom PEGylation analysis services

What is the molecular weight range of PEG molecules detectable by your antibodies?

• Smallest detectable PEG: 750 Da (PEG₂₄)
• Largest detectable PEG: 40 kDa (PEG₉₀₀)

Our antibodies recognize the backbone repeat unit (-O-CH₂-CH₂-), enabling broad detection across linear, branched, and multi-arm PEG structures.