Anti-Human TNFAIP8L2 Polyclonal Antibody (HP334014)

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100ug

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Datasheet

Overview

Catalog No.

HP334014

Description

Anti-Human TNFAIP8L2 Polyclonal Antibody (HP334014) is a rabbit polyclonal antibody detecting TNFAIP8L2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Callithrix jacchus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat, Bos taurus, Callithrix jacchus, Oryctolagus cuniculus, Otolemur garnettii, Papio anubis, Rhinolophus ferrumequinum

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TNFAIP8L2 (Met1-Leu184).

Target

TNF alpha-induced protein 8-like protein 2, Tumor necrosis factor alpha-induced protein 8-like protein 2, TNFAIP8-like protein 2, Inflammation factor protein 20, TIPE2, TNFAIP8L2

Purification

Purified by antigen affinity column.

Accession

Q6P589

RRID

Anti-Human TNFAIP8L2 Polyclonal Antibody (abinScience Cat# HP334014, RRID:AB_3730602)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) is a ~20 kDa protein. Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression. Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness. Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex. Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity.

1. Suo, LG. et al. (2016) Molecular immunology 73, 46-52. PMID: 27043859

2. Lou, Y. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 2122-2132. PMID: 32188758

3. Li, W. et al. (2021) Autophagy 17, 1410-1425. PMID: 32460619

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human TNFAIP8L2 polyclonal antibody at 1ug/mL on recombinant Human TNFAIP8L2 (Catalog No. HP334012).

References

Datasheet

Anti-Human TNFAIP8L2 Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human TNFAIP8L2 Polyclonal Antibody (HP334014)

Overview

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References

Datasheet

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