

| Catalog No. | HP431014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human TWIST2 (Ser60-His160). | ||||||||
| Target | Class A basic helix-loop-helix protein 39, Twist-related protein 2, DERMO1, Dermo-1, BHLHA39, TWIST2, bHLHa39, Dermis-expressed protein 1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q8WVJ9 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Twist-related protein 2 (TWIST2) is a ~18 kDa protein. Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-Human TWIST2 polyclonal antibody at 1ug/mL on recombinant Human TWIST2 (Catalog No. HP431012).



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