Anti-CD203c/ENPP3 Polyclonal Antibody (HT018014)

Name: Anti-CD203c/ENPP3 Polyclonal Antibody
Brand: abinScience
SKU: HT018014
Price: 168 USD
Availability: InStock

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Spec:

50ug
100ug

Number:

Overview
Images
References
Datasheet

Overview

Catalog No.

HT018014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD203c/ENPP3 (Met640-Pro857).

Target

NPPase, PD-Ibeta, Phosphodiesterase I beta, PDNP3, CD203c, Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, E-NPP 3, ENPP3, NPP3, Phosphodiesterase I/nucleotide pyrophosphatase 3, Nucleotide diphosphatase

Purification

Purified by antigen affinity column.

Accession

O14638

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (CD203c/ENPP3) is a ~100 kDa protein. Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response. 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells.

1. Gorelik, A. et al. (2018) The FEBS journal 285, 2481-2494. PMID: 29717535

2. Jin-Hua, P. et al. (1997) Genomics 45, 412-5. PMID: 9344668

3. Mardjuki, R. et al. (2024) Cell reports 43, 114209. PMID: 38749434

4. Vollmayer, P. et al. (2003) European journal of biochemistry 270, 2971-8. PMID: 12846830

5. Bühring, HJ. et al. (2001) Blood 97, 3303-5. PMID: 11342463

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-CD203c/ENPP3 polyclonal antibody at 1ug/mL on recombinant CD203c/ENPP3 (Catalog No. HT018012).

References

Datasheet