

| Catalog No. | HV159014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human NOTCH4 (Asp1715-Lys2002). | ||||||||
| Target | NOTCH4, INT3, hNotch4, Neurogenic locus notch homolog protein 4, Notch 4 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q99466 | ||||||||
| RRID | Anti-NOTCH4 Polyclonal Antibody (abinScience Cat# HV159014, RRID:AB_3722809) |
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| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Neurogenic locus notch homolog protein 4 (NOTCH4) is a ~209 kDa protein. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system. | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-NOTCH4 polyclonal antibody at 1ug/mL on recombinant NOTCH4 (Catalog No. HV159012).



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