Anti-CYP26A1 Polyclonal Antibody (HT346014)

Name: Anti-CYP26A1 Polyclonal Antibody
Brand: abinScience
SKU: HT346014
Price: 168 USD
Availability: InStock

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Spec:

50ug
100ug

Number:

Overview
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References
Datasheet

Overview

Catalog No.

HT346014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CYP26A1 (Arg73-Ile255).

Target

P450RAI1, Cytochrome P450 26A1, Cytochrome P450RAI, hP450RAI, CYP26A1, Cytochrome P450 retinoic acid-inactivating 1, Retinoic acid-metabolizing cytochrome, CYP26, Retinoic acid 4-hydroxylase

Purification

Purified by antigen affinity column.

Accession

O43174

RRID

Anti-CYP26A1 Polyclonal Antibody (abinScience Cat# HT346014, RRID:AB_3723109)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Cytochrome P450 26A1 (CYP26A1) is a ~56 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA.

1. Topletz, AR. et al. (2012) Biochemical pharmacology 83, 149-63. PMID: 22020119

2. White, JA. et al. (1997) The Journal of biological chemistry 272, 18538-41. PMID: 9228017

3. Sonneveld, E. et al. (1998) Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 9, 629-37. PMID: 9716180

4. Foti, RS. et al. (2016) The Journal of pharmacology and experimental therapeutics 357, 281-92. PMID: 26937021

Note

For research use only.

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