

| Catalog No. | HP122014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human UNC13D (Ser888-Pro1090). | ||||||||
| Target | Munc13-4, Protein unc-13 homolog D, UNC13D | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q70J99 | ||||||||
| RRID | Anti-Human UNC13D Polyclonal Antibody (abinScience Cat# HP122014, RRID:AB_3723352) |
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| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Protein unc-13 homolog D (UNC13D) is a ~123 kDa protein. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-Human UNC13D polyclonal antibody at 1ug/mL on recombinant Human UNC13D (Catalog No. HP122012).
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