Anti-Mouse THBS1 Polyclonal Antibody (MY205014)

Name: Anti-Mouse THBS1 Polyclonal Antibody
Brand: abinScience
SKU: MY205014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MY205014

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse THBS1 (Asp27-Gly220).

Target

Thrombospondin 1, Thbs1

Purification

Purified by antigen affinity column.

Accession

P35441

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Thrombospondin-1 (THBS1) is a ~129 kDa protein. Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis. Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis. Ligand for receptor CD47. Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure.

1. Bauer, EM. et al. (2010) Cardiovascular research 88, 471-81. PMID: 20610415

2. Meijles, DN. et al. (2017) Science signaling 10. PMID: 29042481

3. Kaur, S. et al. (2013) Scientific reports 3, 1673. PMID: 23591719

4. Isenberg, JS. et al. (2008) Annals of surgery 247, 180-90. PMID: 18156939

5. Cui, W. et al. (2015) Biochimica et biophysica acta 1852, 1323-33. PMID: 25835637

6. Kong, P. et al. (2013) American journal of physiology. Endocrinology and metabolism 305, E439-50. PMID: 23757408

7. Lynch, JM. et al. (2012) Cell 149, 1257-68. PMID: 22682248

8. Ghimire, K. et al. (2020) Cells 9. PMID: 32679764

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Mouse THBS1 polyclonal antibody at 1ug/mL on recombinant Mouse THBS1 (Catalog No. MY205012).

References

Datasheet

Anti-Mouse THBS1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse THBS1 Polyclonal Antibody (MY205014)

Overview

Images

References

Datasheet

SDS

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