

| Catalog No. | MP087014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Mouse TNFSF18 (Glu50-Ser173). | ||||||||
| Target | Tumor necrosis factor ligand superfamily member 18 (GITR ligand) (GITRL) (Glucocorticoid-induced TNF-related ligand) | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q7TS55 | ||||||||
| RRID | Anti-Mouse TNFSF18 Polyclonal Antibody (abinScience Cat# MP087014, RRID:AB_3723594) |
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| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Tumor necrosis factor ligand superfamily member 18 (TNFSF18/GITRL) is a ~19 kDa protein. Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. 1. Yu, KY. et al. (2003) Biochemical and biophysical research communications 310, 433-8. PMID: 14521928 2. Kim, JD. et al. (2003) Genes and immunity 4, 564-9. PMID: 14647196 3. Tone, M. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 15059-64. PMID: 14608036 4. Ji, HB. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 5823-7. PMID: 15128759 5. Zhou, Z. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 641-5. PMID: 18178614 6. Lacal, PM. et al. (2013) The Journal of pharmacology and experimental therapeutics 347, 164-72. PMID: 23892569 7. Liao, G. et al. (2014) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, 474-84. PMID: 24107315 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-Mouse TNFSF18 polyclonal antibody at 1ug/mL on recombinant Mouse TNFSF18 (Catalog No. MP087012).



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