Anti-Human CCDC22 Polyclonal Antibody (HF586014)

Name: Anti-Human CCDC22 Polyclonal Antibody
Brand: abinScience
SKU: HF586014
Price: 168 USD
Availability: InStock

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Spec:

50ug
100ug

Number:

Overview
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References
Datasheet

Overview

Catalog No.

HF586014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CCDC22 (Met1-Arg107).

Target

Coiled-coil domain-containing protein 22, CCDC22, CXorf37

Purification

Purified by antigen affinity column.

Accession

O60826

RRID

Anti-Human CCDC22 Polyclonal Antibody (abinScience Cat# HF586014, RRID:AB_3723725)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Coiled-coil domain-containing protein 22 (CCDC22) is a ~70 kDa protein. Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex.

1. Healy, MD. et al. (2023) Cell 186, 2219-2237.e29. PMID: 37172566

2. Laulumaa, S. et al. (2024) Nature structural & molecular biology 31, 925-938. PMID: 38459129

3. Starokadomskyy, P. et al. (2013) The Journal of clinical investigation 123, 2244-56. PMID: 23563313

4. Phillips-Krawczak, CA. et al. (2015) Molecular biology of the cell 26, 91-103. PMID: 25355947

5. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human CCDC22 polyclonal antibody at 1ug/mL on recombinant Human CCDC22 (Catalog No. HF586012).

References

Datasheet

Anti-Human CCDC22 Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CCDC22 Polyclonal Antibody (HF586014)

Overview

Images

References

Datasheet

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