Anti-Human TACR1 Polyclonal Antibody (HB146024)

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Datasheet

Overview

Catalog No.

HB146024

Description

Anti-Human TACR1 Polyclonal Antibody (HB146024) is a rabbit polyclonal antibody detecting TACR1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TACR1 (Asn309-Ser407).

Target

Substance-P receptor, SPR, NK-1 receptor, NK-1R, Tachykinin receptor 1, TACR1, NK1R, TAC1R

Purification

Purified by antigen affinity column.

Accession

P25103

RRID

Anti-Human TACR1 Polyclonal Antibody (abinScience Cat# HB146024, RRID:AB_3724559)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Substance-P receptor (TACR1/NK-1R) is a ~46 kDa protein. Receptor for the tachykinin substance P, also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K. The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K. Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP).

1. Takeda, Y. et al. (1991) Biochemical and biophysical research communications 179, 1232-40. PMID: 1718267

2. Randolph, GP. et al. (2004) The pharmacogenomics journal 4, 394-402. PMID: 15452552

Note

For research use only.

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References

Datasheet