Anti-Mouse CD224/GGT1 Polyclonal Antibody (MB811014)

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Overview

Catalog No.

MB811014

Description

Anti-Mouse CD224/GGT1 Polyclonal Antibody (MB811014) is a rabbit polyclonal antibody detecting CD224 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CD224/GGT1 (Arg39-Tyr568).

Target

Glutathione hydrolase 1 proenzyme, 3.4.19.13, Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, GGT 1, 2.3.2.2, Leukotriene-C4 hydrolase, 3.4.19.14, CD224, Glutathione hydrolase 1 heavy chain, Glutathione hydrolase 1 light chain, Ggt1, Ggt, Ggtp

Purification

Purified by antigen affinity column.

Accession

Q60928

RRID

Anti-Mouse CD224/GGT1 Polyclonal Antibody (abinScience Cat# MB811014, RRID:AB_3724712)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Glutathione hydrolase 1 proenzyme (CD224/GGT1) is a ~61 kDa protein. Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. Indirectly regulates multiple aspects of skeletal biology.

1. Levasseur, R. et al. (2003) Endocrinology 144, 2761-4. PMID: 12810527

Note

For research use only.

Images

References

Datasheet

Anti-Mouse CD224/GGT1 Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse CD224/GGT1 Polyclonal Antibody (MB811014)

Overview

Images

References

Datasheet

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