Anti-HRSV-A/B G/Major surface glycoprotein G Antibody (131-2G) (VK562033)

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Datasheet

Overview

Catalog No.

VK562033

Description

Anti-HRSV-A/B G/Major surface glycoprotein G Antibody (131-2G) [131-2G] (VK562033) is a human monoclonal antibody detecting Major surface glycoprotein G in ELISA, IF.

Species reactivity

Human respiratory syncytial virus A/B

Applications

ELISA, IF

Host species

Human

Isotype

IgG1, kappa

Clone ID

131-2G

Clonality

Monoclonal

Target

G, Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG, RSV

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P03423

RRID

Anti-HRSV-A/B G/Major surface glycoprotein G Antibody (131-2G) (abinScience Cat# VK562033, RRID:AB_3725265)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Major surface glycoprotein G is a ~32 kDa protein. Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).

1. Feldman, SA. et al. (1999) Journal of virology 73, 6610-7. PMID: 10400758

2. Feldman, SA. et al. (2000) Journal of virology 74, 6442-7. PMID: 10864656

3. Levine, S. et al. (1987) The Journal of general virology 68 ( Pt 9), 2521-4. PMID: 3655746

4. Tripp, RA. et al. (2001) Nature immunology 2, 732-8. PMID: 11477410

5. Jeong, KI. et al. (2015) PloS one 10, e0130517. PMID: 26107373

6. Johnson, SM. et al. (2015) PLoS pathogens 11, e1005318. PMID: 26658574

Note

For research use only.

Images

Bioactivity

Detects Recombinant HRSV G/Major surface glycoprotein G Protein, C-His (Cat No.: VK562011) in indirect ELISA.
SDS-PAGE

SDS-PAGE for Anti-HRSV-A/B G/Major surface glycoprotein G Antibody (131-2G)