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InVivoMAb Anti-Human LRP6 Antibody (YW210.09) (HF964010)

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InVivoMAb Anti-Human LRP6 Antibody (YW210.09)

InVivoMAb Anti-Human LRP6 Antibody (YW210.09)

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100ug
1mg

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Datasheet

Overview

Catalog No.	HF964010
Description	InVivoMAb Anti-Human LRP6 Antibody (YW210.09) [YW210.09] (HF964010) is a mouse monoclonal antibody detecting LRP6 in ELISA, Neutralization, SPR. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, Neutralization, SPR
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	YW210.09
Clonality	Monoclonal
Target	LRP6, LRP-6, Low-density lipoprotein receptor-related protein 6
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O75581
RRID	InVivoMAb Anti-Human LRP6 Antibody (YW210.09) (abinScience Cat# HF964010, RRID:AB_3727803)
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Low-density lipoprotein receptor-related protein 6 (LRP6) is a ~180 kDa protein. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in various processes including retinal angiogenesis and bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. 1. Mao, B. et al. (2001) Nature 411, 321-5. PMID: 11357136 2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771 3. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503 4. Zeng, X. et al. (2005) Nature 438, 873-7. PMID: 16341017 5. Swiatek, W. et al. (2006) The Journal of biological chemistry 281, 12233-41. PMID: 16513652 6. Mi, K. et al. (2007) Journal of neurochemistry 101, 517-29. PMID: 17326769 7. Wei, Q. et al. (2007) The Journal of biological chemistry 282, 15903-11. PMID: 17400545 8. Piao, S. et al. (2008) PloS one 3, e4046. PMID: 19107203 9. Wu, G. et al. (2009) PloS one 4, e4926. PMID: 19293931 10. Chen, M. et al. (2009) The Journal of biological chemistry 284, 35040-8. PMID: 19801552
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for InVivoMAb Anti-Human LRP6 Antibody (YW210.09)

References

Datasheet

InVivoMAb Anti-Human LRP6 Antibody (YW210.09).pdf

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InVivoMAb Anti-Human LRP6 Antibody (YW210.09)