Anti-Mexican scorpion Beta-toxin Cl13/Cb3 Antibody (4B) (ZA029023)

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50ug
100ug
1mg

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Overview
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Datasheet

Overview

Catalog No.

ZA029023

Description

Anti-Mexican scorpion Beta-toxin Cl13/Cb3 Antibody (4B) [4B] (ZA029023) is a mouse monoclonal antibody detecting Beta-toxin Cl13 in ELISA, Neutralization, SPR.

Highlights

●Multi-Application — Validated across multiple applications.

Species reactivity

Centruroides limpidus (Mexican scorpion), Centruroides baergi (Scorpion) (Centruroides nigrovariatus baergi)

Applications

ELISA, Neutralization, SPR

Host species

Mouse

Isotype

IgG2a

Clone ID

Clonality

Monoclonal

Target

Beta-toxin Cl13, CliNaTxBet37, Beta-toxin Cb3, Centruroides limpidus (Mexican scorpion), Centruroides baergi (Scorpion) (Centruroides nigrovariatus baergi)

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

C0HK69, C0HLR5

RRID

Anti-Mexican scorpion Beta-toxin Cl13/Cb3 Antibody (4B) (abinScience Cat# ZA029023, RRID:AB_3729011)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Beta-toxin Cl13 (Cb3) is a ~8 kDa protein. Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Inhibits sodium channels Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A. Also has a weak inhibitory effect on Nav1.2/SCN2A. Is lethal to mice.

1. Olamendi-Portugal, T. et al. (2017) Peptides 87, 34-40. PMID: 27871874

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Mexican scorpion Beta-toxin Cl13/Cb3 Antibody (4B)

References

Datasheet

Anti-Mexican scorpion Beta-toxin Cl13/Cb3 Antibody (4B).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mexican scorpion Beta-toxin Cl13/Cb3 Antibody (4B) (ZA029023)

Overview

Images

References

Datasheet

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