Anti-SARS-CoV-2 Nucleoprotein Polyclonal Antibody (VK805024)

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Overview

Catalog No.

VK805024

Description

Anti-SARS-CoV-2 Nucleoprotein Polyclonal Antibody (VK805024) is a rabbit polyclonal antibody detecting Nucleoprotein. Suitable for Severe acute respiratory syndrome coronavirus 2, Bat coronavirus HKU3, Bat coronavirus 279/2005, Severe acute respiratory syndrome coronavirus, and Bat coronavirus Rp3/2004.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Severe acute respiratory syndrome coronavirus 2, Bat coronavirus HKU3, Bat coronavirus 279/2005, Severe acute respiratory syndrome coronavirus, Bat coronavirus Rp3/2004

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant SARS-CoV-2 Nucleoprotein (Asn47-Ala173).

Target

N, NC, Nucleocapsid protein, Nucleoprotein, Protein N

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P0DTC9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Nucleoprotein is a ~45 kDa protein. Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Attenuates the stress granules formation by reducing host G3BP1 access to host mRNAs under stress conditions.

1. Dinesh, DC. et al. (2020) PLoS pathogens 16, e1009100. PMID: 33264373

2. Nabeel-Shah, S. et al. (2022) iScience 25, 103562. PMID: 34901782

3. Dolliver, SM. et al. (2022) PLoS pathogens 18, e1011041. PMID: 36534661

Note

For research use only

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References

Datasheet