Anti-Human IRF7 Polyclonal Antibody (HD620014)

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Datasheet

Overview

Catalog No.

HD620014

Description

Anti-Human IRF7 Polyclonal Antibody (HD620014) is a rabbit polyclonal antibody detecting IRF7. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IRF7 (Leu289-Ala503).

Target

IRF-7, IRF7, Interferon regulatory factor 7

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q92985

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Interferon regulatory factor 7 (IRF7) is a ~54 kDa protein. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase.

1. Hwang, SW. et al. (2017) Biochemical and biophysical research communications 486, 700-705. PMID: 28342865

2. Kitagawa, Y. et al. (2017) Journal of virology 91. PMID: 28768858

3. Panne, D. et al. (2007) Cell 129, 1111-23. PMID: 17574024

4. Zhang, Q. et al. (2020) Science (New York, N.Y.) 370. PMID: 32972995

5. Marié, I. et al. (2000) Molecular and cellular biology 20, 8803-14. PMID: 11073981

6. Caillaud, A. et al. (2002) The Journal of biological chemistry 277, 49417-21. PMID: 12374802

7. Kawai, T. et al. (2004) Nature immunology 5, 1061-8. PMID: 15361868

8. Sgarbanti, M. et al. (2007) Annals of the New York Academy of Sciences 1095, 325-33. PMID: 17404045

Note

For research use only

Images

References

Datasheet

Anti-Human IRF7 Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

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Anti-Human IRF7 Polyclonal Antibody (HD620014)

Overview

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References

Datasheet

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