Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody (VK138014)

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Overview
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Datasheet

Overview

Catalog No.

VK138014

Description

Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody (VK138014) is a rabbit polyclonal antibody detecting Outer capsid protein sigma-1. Suitable for Reovirus type 1.

Species reactivity

Reovirus type 1

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Reovirus Outer capsid protein sigma-1 (Val258-Arg470).

Target

Cell attachment protein, Hemagglutinin, Outer capsid protein sigma-1, S1, Sigma1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P04506

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Outer capsid protein sigma-1 is a ~51 kDa protein. Fiber-like molecule that attaches the virion to the host cell membrane by binding with initial low affinity to sialic acid containing proteins, followed by high-affinity bindingto the entry receptor F11R/JAM-A. Also binds to the ganglioside GM2 as an alternate receptor, this binding is serotype-specific. The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis.

1. Reiss, K. et al. (2012) PLoS pathogens 8, e1003078. PMID: 23236285

Note

For research use only

Images

References

Datasheet

Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody (VK138014)

Overview

Images

References

Datasheet

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