Anti-Human IL1RL1/ST2 antibody (CNTO3914) (HX139013)

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Datasheet

Overview

Catalog No.

HX139013

Description

Anti-Human IL1RL1/ST2 antibody (CNTO3914) [CNTO3914] (HX139013) is a human monoclonal antibody detecting Protein ST2 in ELISA, WB. Suitable for Human.

Species reactivity

Human

Applications

ELISA, WB

Host species

Human

Isotype

IgG1

Clone ID

CNTO3914

Clonality

Monoclonal

Target

T1, DER4, Interleukin-1 receptor-like 1, ST2, IL1RL1, Protein ST2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q01638

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~63 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.

1. Yi, XM. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2116279119. PMID: 35238669

2. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016

Note

For research use only.

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