Anti-CD183/CXCR3 Polyclonal Antibody (HW606014)

Datasheet Share product Copy info

Price(USD): $

Spec:

50ug
100ug

Number:

Overview
Images
References
Datasheet

Overview

Catalog No.

HW606014

Description

Anti-CD183/CXCR3 Polyclonal Antibody (HW606014) is a rabbit polyclonal antibody detecting CXCR3 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD183/CXCR3 (Met1-Arg53).

Target

CXCR3, G protein-coupled receptor 9, CXC-R3, Interferon-inducible protein 10 receptor, IP-10 receptor, C-X-C chemokine receptor type 3, GPR9, CD183, CKR-L2, CXCR-3

Purification

Purified by antigen affinity column.

Accession

P49682

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

C-X-C chemokine receptor type 3 (CD183/CXCR3) is a ~40 kDa protein. Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling.

1. Lasagni, L. et al. (2003) The Journal of experimental medicine 197, 1537-49. PMID: 12782716

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-CD183/CXCR3 polyclonal antibody at 1ug/mL on recombinant CD183/CXCR3 (Catalog No. HW606012).

References

Datasheet