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Anti-Human CD98/SLC3A2 Antibody (Ab110) (HY415107)

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Anti-Human CD98/SLC3A2 Antibody (Ab110)

Anti-Human CD98/SLC3A2 Antibody (Ab110)

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Overview

Catalog No.	HY415107
Description	Anti-Human CD98/SLC3A2 Antibody (Ab110) [Ab110] (HY415107) is a mouse monoclonal antibody detecting SLC3A2 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	Ab110
Clonality	Monoclonal
Target	SLC3A2, 4F2hc, Lymphocyte activation antigen 4F2 large subunit, CD98, 4F2 cell-surface antigen heavy chain, Solute carrier family 3 member 2, MDU1, 4F2 heavy chain antigen
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P08195
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Amino acid transporter heavy chain SLC3A2 (CD98) is a ~57 kDa protein. Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters. Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. 1. Rossier, G. et al. (1999) The Journal of biological chemistry 274, 34948-54. PMID: 10574970 2. Bröer, A. et al. (2000) The Biochemical journal 349 Pt 3, 787-95. PMID: 10903140 3. Yanagida, O. et al. (2001) Biochimica et biophysica acta 1514, 291-302. PMID: 11557028 4. Yan, R. et al. (2019) Nature 568, 127-130. PMID: 30867591 5. Yan, R. et al. (2020) Cell discovery 6, 82. PMID: 33298890 6. Yan, R. et al. (2021) Cell discovery 7, 16. PMID: 33758168 7. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232 8. Mastroberardino, L. et al. (1998) Nature 395, 288-91. PMID: 9751058 9. Torrents, D. et al. (1998) The Journal of biological chemistry 273, 32437-45. PMID: 9829974 10. Pfeiffer, R. et al. (1999) The EMBO journal 18, 49-57. PMID: 9878049
Note	For research use only.

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Bioactivity

SEC-HPLC detection for Anti-Human CD98/SLC3A2 Antibody (Ab110).

References

Datasheet

Anti-Human CD98/SLC3A2 Antibody (Ab110).pdf

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Anti-Human CD98/SLC3A2 Antibody (Ab110)