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Anti-Human CD349/FZD9 Antibody (2933#), APC (HT468137)

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Overview

Catalog No.	HT468137
Description	Anti-Human CD349/FZD9 Antibody (2933#), APC [2933#] (HT468137) is a mouse monoclonal antibody detecting CD349 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	2933#
Conjugation	APC
Clonality	Monoclonal
Target	FzE6, Frizzled-9, FZD9, FZD3, hFz9, CD349, Fz-9
Endotoxin level	Please contact with the lab for this information.
Accession	O00144
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Frizzled-9 (CD349/FZD9) is a ~64 kDa protein. Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. 1. Chailangkarn, T. et al. (2016) Nature 536, 338-43. PMID: 27509850
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Human CD349/FZD9 Antibody (2933#), APC.pdf

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Anti-Human CD349/FZD9 Antibody (2933#), APC