Anti-Human LGR4 Antibody (SAA0107), APC (HV980137)

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Catalog No.	HV980137
Description	Anti-Human LGR4 Antibody (SAA0107), APC [SAA0107] (HV980137) is a human monoclonal antibody detecting LGR4 in ELISA, FCM, WB. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	ELISA, FCM, WB
Host species	Human
Isotype	IgG1
Clone ID	SAA0107
Conjugation	APC
Clonality	Monoclonal
Target	GPR48, Leucine-rich repeat-containing G-protein coupled receptor 4, LGR4, G-protein coupled receptor 48, RHJ50601
Endotoxin level	Please contact with the lab for this information.
Accession	Q9BXB1
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) is a ~104 kDa protein. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo.
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human LGR4 Antibody (SAA0107), APC.pdf

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Anti-Human LGR4 Antibody (SAA0107), APC (HV980137)

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