Anti-Human CD245/MYO18A Antibody (DY12), PE (HV061127)

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Overview

Catalog No.	HV061127
Description	Anti-Human CD245/MYO18A Antibody (DY12), PE [DY12] (HV061127) is a mouse monoclonal antibody detecting MYO18A in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	DY12
Conjugation	PE
Clonality	Monoclonal
Target	CD245, Myosin containing a PDZ domain, MAJN, SP-R210, Surfactant protein receptor SP-R210, MYO18A, MYSPDZ, Unconventional myosin-XVIIIa, KIAA0216, Molecule associated with JAK3 N-terminus
Endotoxin level	Please contact with the lab for this information.
Accession	Q92614
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Unconventional myosin-XVIIIa (CD245/MYO18A) is a ~233 kDa protein. May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. 1. Dippold, HC. et al. (2009) Cell 139, 337-51. PMID: 19837035 2. Ng, MM. et al. (2013) Molecular biology of the cell 24, 796-808. PMID: 23345592 3. Tan, I. et al. (2008) Cell 135, 123-36. PMID: 18854160 4. Yang, L. et al. (2015) PloS one 10, e0126576. PMID: 25965346 5. Yang, CH. et al. (2005) The Journal of biological chemistry 280, 34447-57. PMID: 16087679 6. Sever-Chroneos, Z. et al. (2011) The Journal of biological chemistry 286, 4854-70. PMID: 21123169 7. De Masson, A. et al. (2016) Oncoimmunology 5, e1127493. PMID: 27467939
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD245/MYO18A Antibody (DY12), PE.pdf

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Anti-Human CD245/MYO18A Antibody (DY12), PE (HV061127)

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