InVivoMAb Anti-Human Dkk-1 Antibody (DKN-01) (HF914010)

Name: InVivoMAb Anti-Human Dkk-1 Antibody (DKN-01)
Brand: abinScience
SKU: HF914010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Overview

Catalog No.	HF914010
Description	InVivoMAb Anti-Human DKK1 Antibody (DKN-01) [DKN-01] (HF914010) is a mouse monoclonal antibody detecting Dickkopf-1 in ELISA, Neutralization. Suitable for Human.
Species reactivity	Human
Applications	ELISA, Neutralization
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	DKN-01
Clonality	Monoclonal
Target	Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O94907
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Dickkopf-related protein 1 (DKK1) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. 1. Ahn, VE. et al. (2011) Developmental cell 21, 862-73. PMID: 22000856 2. Niehrs, C. (2006) Oncogene 25, 7469-81. PMID: 17143291
Note	For research use only. Not suitable for clinical or therapeutic use.