| Catalog No. | HP900016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | [scFv-heavy-kappa-TNF(tumornecrosisfactor(TNF)superfamilymember2, TNFSF2, TNF-alpha, TNFA)]-trimer |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | EDB, EDB-FN |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P02751-7 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | L19TNF, L19TNF-alpha, 1957239-88-1 |
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| Background | Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research.
• EDB-FN targeted probes for the surgical navigation, radionuclide imaging, and therapy of thyroid cancer., PMID:36807768
• EDB-FN Targeted Peptide-Drug Conjugates for Use against Prostate Cancer., PMID:31277465
• EDB-FN-targeted probes for near infrared fluorescent imaging and positron emission tomography imaging of breast cancer in mice., PMID:39333775
• Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade., PMID:35793468
• Evaluation of EDB Fibronectin in Plasma, Patient-Derived Xenograft Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tumor Tissues Using Immunoaffinity LC-MS/MS., PMID:36049057
• EDB Fibronectin-Specific SPECT Probe 99mTc-HYNIC-ZD2 for Breast Cancer Detection., PMID:30023665
• Tenascin-C: Form versus function., PMID:25482829
• EDB Fibronectin Specific Peptide for Prostate Cancer Targeting., PMID:25848940
• EDB fibronectin and angiogenesis -- a novel mechanistic pathway., PMID:16308732
• RT-PCR detection of fibronectin EDA+ and EDB+ mRNA isoforms: molecular markers for hepatocellular carcinoma., PMID:7509777
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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