Anti-Ticagrelor Reference Antibody (Bentracimab, RUO) (YP489016)

Name: Anti-Ticagrelor Reference Antibody (Bentracimab, RUO)
Brand: abinScience
SKU: YP489016
Price: 482 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

YP489016

Description

Bentracimab (YP489016) is a research-grade recombinant antibody targeting Ticagrelor. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Species reactivity

General

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Host species

Human

Isotype

Fab-G1-lambda

Clone ID

274693-27-5

Expression system

Mammalian cells

Clonality

Monoclonal

Target

Ticagrelor

Endotoxin level

Please contact the lab for this information.

Purity

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

CAS: 274693-27-5

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

MEDI2452, anti-ticagrelor, antidote for ticagrelor, CAS: 274693-27-5

Background

Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor.
• Ticagrelor., PMID:35396017
• Ticagrelor with or without Aspirin in High-Risk Patients after PCI., PMID:31556978
• Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis., PMID:38506796
• Ticagrelor: clinical development and future potential., PMID:34258905
• Ticagrelor resistance: a case series and algorithm for management of non-responders., PMID:34215660
• Is ticagrelor worth its high cost and side-effects?, PMID:29730968
• Ticagrelor in stable coronary disease., PMID:37586825
• Ticagrelor-Associated Urticaria., PMID:35639409
• Ticagrelor Use in Stroke Patients: Past, Present, and Future., PMID:34163168
• Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial., PMID:32334703

Note

For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Bentracimab

References

Datasheet

Anti-Ticagrelor Reference Antibody (Bentracimab, RUO).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Ticagrelor Reference Antibody (Bentracimab, RUO) (YP489016)

Overview

Images

References

Datasheet

SDS

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