| Catalog No. | YP489016 |
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| Species reactivity | General |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | Fab-G1-lambda |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Ticagrelor |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | 274693-27-5 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | MEDI2452, anti-ticagrelor, antidoteforticagrelor, 274693-27-5 |
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| Background | Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor (HY-1006) and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor.
• Ticagrelor., PMID:35396017
• Ticagrelor with or without Aspirin in High-Risk Patients after PCI., PMID:31556978
• Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis., PMID:38506796
• Ticagrelor: clinical development and future potential., PMID:34258905
• Ticagrelor resistance: a case series and algorithm for management of non-responders., PMID:34215660
• Is ticagrelor worth its high cost and side-effects?, PMID:29730968
• Ticagrelor in stable coronary disease., PMID:37586825
• Ticagrelor-Associated Urticaria., PMID:35639409
• Ticagrelor Use in Stroke Patients: Past, Present, and Future., PMID:34163168
• Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial., PMID:32334703
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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