Anti-Human GDNF Reference Antibody (Nadecnemab, RUO) (HT009016)

Name: Anti-Human GDNF Reference Antibody (Nadecnemab, RUO)
Brand: abinScience
SKU: HT009016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HT009016
Description	Nadecnemab (HT009016) is a research-grade recombinant antibody targeting GFR-alpha-3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4-Kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	GFR-alpha-3, GDNF receptor alpha-3, GDNF family receptor alpha-3, GDNFR-alpha-3, GFRA3
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O60609
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	REGN5069, 2377679-19-9
Background	GDNF family receptor alpha-3 (GFRA3) is a ~44 kDa protein. Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor. 1. Li, J. et al. (2019) eLife 8. PMID: 31535977 2. Baloh, RH. et al. (1998) Neuron 21, 1291-302. PMID: 9883723
Note	For research use only. Not suitable for clinical or therapeutic use.

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SEC-HPLC

SEC-HPLC detection for Research Grade Nadecnemab.
Bioactivity

Detects GFRA3 in indirect ELISAs.

References

Datasheet

Anti-Human GDNF Reference Antibody (Nadecnemab, RUO).pdf

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Recombinant Proteins

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Anti-Human GDNF Reference Antibody (Nadecnemab, RUO) (HT009016)

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