| Catalog No. | HT009016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG4-Kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
GFR-alpha-3, GDNF receptor alpha-3, GDNF family receptor alpha-3, GDNFR-alpha-3, GFRA3 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
O60609 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | REGN5069, 2377679-19-9 |
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| Background | Nadecnemab is an IgG4κ antibody targeting to GFRA3, glial cell derived neurotrophic factor family receptor alpha 3. Nadecnemab can be used for research of osteoarthritis of the knee/pain.
• Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha., PMID:9535755
• GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin., PMID:9740802
• GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia., PMID:11745618
• Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase., PMID:9608533
• Glial cell line-derived neurotrophic factor is expressed in penis of adult rat and retrogradely transported in penile parasympathetic and sensory nerves., PMID:11151444
• The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction., PMID:15204970
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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