Research Grade Anti-Human CD85k/LILRB4/ILT3 (BND-35) (HV126026)

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100ug
1mg

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Overview

Catalog No.	HV126026
Description	Anti-Human CD85k/LILRB4/ILT3 (BND-35) (HV126026) is a research-grade recombinant antibody targeting CD85. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	BND-35
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	CD85 antigen-like family member K, LIR-5, Leukocyte immunoglobulin-like receptor 5, ILT3, ILT-3, Immunoglobulin-like transcript 3, LILRB4, CD85k, Leukocyte immunoglobulin-like receptor subfamily B member 4, Monocyte inhibitory receptor HM18, LIR5
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q8NHJ6
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	BND-35, BND35, BND35
Background	Leukocyte immunoglobulin-like receptor subfamily B member 4 (CD85k/LILRB4) is a ~49 kDa protein. Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 1. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462 2. Su, MT. et al. (2021) International immunology 33, 447-458. PMID: 34089617 3. Deng, M. et al. (2018) Nature 562, 605-609. PMID: 30333625 4. Xu, Z. et al. (2018) Journal of immunology (Baltimore, Md. : 1950) 200, 1207-1219. PMID: 29263213 5. Cella, M. et al. (1997) The Journal of experimental medicine 185, 1743-51. PMID: 9151699 6. Lu, HK. et al. (2009) The Journal of biological chemistry 284, 34839-48. PMID: 19833736 7. Kim-Schulze, S. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 2790-8. PMID: 16493035
Note	For research use only. Not suitable for clinical or therapeutic use.