| Catalog No. | HV166066 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2, TREM2 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q9NZC2 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2733621-19-5 |
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| Background | Iluzanebart is a human IgG1κ antibody targeting TREM2, a triggering receptor expressed on myeloid cells.
• Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma., PMID:38237157
• TREM2, microglia, and Alzheimer's disease., PMID:33516818
• Distinct roles of TREM2 in central nervous system cancers and peripheral cancers., PMID:38788719
• TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration., PMID:37442133
• TREM2, Microglia, and Neurodegenerative Diseases., PMID:28442216
• Microglia and TREM2., PMID:38821351
• TREM2 dependent and independent functions of microglia in Alzheimer's disease., PMID:36564824
• TREM2: A new player in the tumor microenvironment., PMID:36989543
• TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis., PMID:33586673
• How neuroinflammation contributes to neurodegeneration., PMID:27540165
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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