| Catalog No. | HV166066 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Human |
|---|
| Isotype | IgG1-kappa |
|---|
| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2, TREM2 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
Q9NZC2 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | 2733621-19-5 |
|---|
| Background | Iluzanebart is a human IgG1κ antibody targeting TREM2, a triggering receptor expressed on myeloid cells.
• Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma., PMID:38237157
• TREM2, microglia, and Alzheimer's disease., PMID:33516818
• Distinct roles of TREM2 in central nervous system cancers and peripheral cancers., PMID:38788719
• TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration., PMID:37442133
• TREM2, Microglia, and Neurodegenerative Diseases., PMID:28442216
• Microglia and TREM2., PMID:38821351
• TREM2 dependent and independent functions of microglia in Alzheimer's disease., PMID:36564824
• TREM2: A new player in the tumor microenvironment., PMID:36989543
• TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis., PMID:33586673
• How neuroinflammation contributes to neurodegeneration., PMID:27540165
|
|---|
| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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