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Recombinant Human CD167b/DDR2 Protein, C-His (HS877011)

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Recombinant Human CD167b/DDR2 Protein, C-His

Recombinant Human CD167b/DDR2 Protein, C-His

Recombinant Human CD167b/DDR2 Protein, C-His

Recombinant Human CD167b/DDR2 Protein, C-His

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Datasheet

Overview

Catalog No.	HS877011
Description	Recombinant Human CD167b/DDR2 Protein, C-His (HS877011) expressed in Mammalian Cells, spanning Met1-Arg399. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian Cells
Accession	Q16832
Protein length	Met1-Arg399
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	46.02 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Discoidin domain-containing receptor 2, Discoidin domain receptor 2, Tyrosine-protein kinase TYRO10, TKT, TYRO10, CD167b, Discoidin domain-containing receptor tyrosine kinase 2, Receptor protein-tyrosine kinase TKT, DDR2, Neurotrophic tyrosine kinase, receptor-related 3, NTRKR3, CD167 antigen-like family member B
Background	Discoidin domain-containing receptor 2 (CD167b/DDR2) is a ~96 kDa protein. Tyrosine kinase involved in the regulation of tissues remodeling. It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. 1. Xu, L. et al. (2018) American journal of human genetics 103, 976-983. PMID: 30449416
Note	For research use only.

Images

SDS-PAGE

SDS-PAGE for Recombinant Human CD167b/DDR2 Protein, C-His
Bioactivity

Detected by SAA0978 (Catalog No: HS877013) in indirect ELISA.

References

HS877011-SDS-PAGE-1.jpg

Datasheet

Recombinant Human CD167b/DDR2 Protein, C-His.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

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Working Solution

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Recombinant Human CD167b/DDR2 Protein, C-His