Human MYD88 Recombinant Protein (N-His) (HV517012)

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Catalog No.	HV517012
Description	Recombinant Human MYD88 Protein, N-His (HV517012) expressed in E. coli, spanning Met157-Pro296. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q99836
Protein length	Met157-Pro296
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	18.58 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MYD88, Myeloid differentiation primary response protein MyD88
Background	Myeloid differentiation primary response protein MyD88 is a ~33 kDa protein. Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. 1. Kawai, T. et al. (2004) Nature immunology 5, 1061-8. PMID: 15361868 2. Semaan, N. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 3485-91. PMID: 18292575 3. Campbell, GR. et al. (2021) iScience 24, 102295. PMID: 33718825 4. Duan, T. et al. (2023) EMBO reports 24, e57828. PMID: 37971847 5. Ohnishi, H. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 10260-5. PMID: 19506249 6. Yamamoto, T. et al. (2014) Molecular immunology 58, 66-76. PMID: 24316379 7. Kumar, R. et al. (2025) Journal of virology 99, e0041425. PMID: 40638072 8. Bonnert, TP. et al. (1997) FEBS letters 402, 81-4. PMID: 9013863
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Recombinant Human MYD88 Protein, N-His

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HV517012-SDS-PAGE-1.jpg

Datasheet

Human MYD88 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Human MYD88 Recombinant Protein (N-His) (HV517012)

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