Recombinant Human TRPM4 Protein, N-GST & C-His (HP790032)

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Overview

Catalog No.	HP790032
Description	Recombinant Human TRPM4 Protein, N-GST & C-His (HP790032) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q8TD43
Protein length	Leu952-Leu1019
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Calcium-activated non-selective cation channel 1, LTRPC4, LTrpC-4, LTrpC4, Long transient receptor potential channel 4, Melastatin-4, TRPM4, Transient receptor potential cation channel subfamily M member 4, hTRPM4
Background	Transient receptor potential cation channel subfamily M member 4 is a ~134 kDa protein. Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. 1. Launay, P. et al. (2002) Cell 109, 397-407. PMID: 12015988 2. Hofmann, T. et al. (2003) Current biology : CB 13, 1153-8. PMID: 12842017 3. Winkler, PA. et al. (2017) Nature 552, 200-204. PMID: 29211723 4. Wang, H. et al. (2019) The Journal of investigative dermatology 139, 1089-1097. PMID: 30528822
Note	For research use only

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Datasheet

Recombinant Human TRPM4 Protein, N-GST & C-His.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Recombinant Human TRPM4 Protein, N-GST & C-His (HP790032)

Overview

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Datasheet

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