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InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9) (VK749040)

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InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9)

InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9)

InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9)

InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9)

InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9)

InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9)

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Spec:

100ug
1mg

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Datasheet

Overview

Catalog No.	VK749040
Description	InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9) [28D9] (VK749040) is a mouse monoclonal antibody detecting Spike glycoprotein in ELISA, Neutralization.
Species reactivity	SARS-CoV-2 (2019-nCoV)
Applications	ELISA, Neutralization
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	28D9
Clonality	Monoclonal
Target	Spike glycoprotein, S glycoprotein, Spike protein S2, S, 2, SARS-CoV-2 (2019-nCoV)
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P0DTC2
RRID	InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9) (abinScience Cat# VK749040, RRID:AB_3727806)
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Spike glycoprotein (Spike glycoprotein 2) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9)
Bioactivity

Detects recombinant SARS-CoV-2 spike protein S2 in indirect ELISA
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: ATGE5729 200ng
Lane 2: 1* loading buffer

References

Datasheet

InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9).pdf

Formula

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InVivoMAb Anti-SARS-CoV-2 S2/Spike glycoprotein 2 Antibody (28D9)