InVivoMAb Anti-Mouse IL11 Antibody (Iv0284) (MB978010)

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Overview

Catalog No.	MB978010
Description	InVivoMAb Anti-Mouse IL11 Antibody (Iv0284) [Iv0284] (MB978010) is a mouse monoclonal antibody detecting Interleukin-11 in ELISA, FCM, Neutralization, WB, in vivo research. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	ELISA, FCM, Neutralization, WB, in vivo research
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	Iv0284
Clonality	Monoclonal
Target	Interleukin-11, IL-11, Il11
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P47873
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Morris, JC. et al. (1996) Experimental hematology 24, 1369-76. PMID: 8913282 2. Nishina, T. et al. (2012) Science signaling 5, ra5. PMID: 22253262 3. Barton, VA. et al. (1999) The Journal of biological chemistry 274, 5755-61. PMID: 10026196 4. Putoczki, TL. et al. (2013) Cancer cell 24, 257-71. PMID: 23948300
Note	For research use only.

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SDS-PAGE for InVivoMAb Anti-Mouse IL11 Antibody (Iv0284)

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Datasheet

InVivoMAb Anti-Mouse IL11 Antibody (Iv0284).pdf

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InVivoMAb Anti-Mouse IL11 Antibody (Iv0284) (MB978010)

Overview

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References

Datasheet

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